Most of the animal matches to the candidate lost genes correspond to lineage-specific horizontal gene transfers and/or environmental contaminants from unrelated (non-opisthokont) clades. e., not orthologous) to the named yeast gene (first column) for all matches with BLASTP expectation values < 1e-20. This table shows either the taxonomic origin of a weak animal match, or the name of the gene if it is not directly related ( i. ( B) Close-up of the lost animal gene columns from panel A. The last row is from an alternative screen for lost animal genes (see text) in which Amoebozoa PFAM domains that are absent in animals were identified (five genes already identified plus one new gene, PURB). Other abbreviations: Chytridio., Chytridiomycota Placo., Placozoa Ctenoph., Ctenophora Ecdyso., Ecdysozoa and Chor., Chordata. The heat map is based on the BLASTP expect values of the best match to the indicated yeast gene (see key, lower right of table). Six of the twenty-seven yeast genes are the result of lineage-specific duplications in yeast (indicated by dark gray brackets, left of table), leaving twenty-four genetic functions either lost or not measurably conserved in metazoans. cer.) and their orthologs in related organisms with whole genome sequence assemblies and their closest matches in animals. ( A) Heat map of twenty-seven genes (first twenty-seven rows with gene names) from the budding yeast S. Twenty-five genetic functions undetectable in animals.
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